血捐赠者的安全和保护:范围审查和证据差距地图
Natalie Schroyens1,2, Tine D'aes1, Emmy De Buck1,2
1Centre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.
Vox sanguinis
|October 10, 2023
概括
本次审查确定了有关血捐赠者的不良事件的证据缺口. 需要更多的受控研究来确定安全的捐赠频率和长期健康影响.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 医学研究 医学研究
背景情况:
- 欧洲不断增加的血采集需要了解供体安全.
- 现有的关于不良事件 (AE) 和血酶捐赠者的健康影响的证据是零碎的.
- 识别与AE相关的因素对于捐赠者福祉至关重要.
研究的目的:
- 进行对plasmapheresis捐赠者的不良事件和健康影响的证据的范围审查.
- 识别当前研究中关于血酶供体安全性的差距.
- 为决策者和研究人员提供有关安全血采集证据的信息.
主要方法:
- 在6个数据库和3个注册表中进行了全面的搜索.
- 提取了研究特征,包括设计,人口,结果和相关因素.
- 数据以叙事方式合成,并在交互式证据差距地图中可视化.
主要成果:
- 确定了94篇文章和5项注册,主要是观察性研究 (90%).
- 大多数研究来自欧洲 (55%) 和美国 (20%).
- 捐赠者的特征,捐赠频率和血采集设备是经常研究的因素.
结论:
- 该审查提供了一种工具,以识别血酶供体安全方面的证据缺口.
- 有一个可控的,前性研究的稀缺性,与长期的供体随访.
- 需要进一步的实验研究来确定捐赠频率的安全上限.
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