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早期乳腺癌查中的KRT15和与HER2阳性,病理等级和N期的相关性

Zijing Zhang¹, Hongying Wang¹, Yiting Jin¹

¹Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Biomarkers in medicine

|October 10, 2023

概括

氨酸15 (KRT15) 表达有助于区分侵袭性乳腺癌与 in situ 管道癌. KRT15可能有助于早期发现乳腺癌并了解疾病特征.

科学领域:

在瘤学瘤学.
生物标志物研究生物标志物研究

背景情况:

氨酸15 (KRT15) 是一种涉及上皮细胞分化的蛋白质.
了解KRT15在乳腺癌进展中的作用对于早期检测和治疗策略至关重要.

研究的目的:

为了研究KRT15的失调在管道癌 in situ (DCIS),DCIS与微侵袭 (DCIS-MI) 和侵袭性乳腺癌 (IBC).
为了将KRT15表达与这些乳腺癌亚型的临床和病理特征相关联.

主要方法:

免疫组织化学用于检测50名DCIS,48名DCIS-MI和50名IBC患者的病变样本中的KRT15表达.
进行了统计分析,包括曲线下的面积 (AUC) 和相关性测试.

主要成果:

KRT15有效地将IBC与DCIS (AUC=0.895) 和DCIS-MI (AUC=0.707) 进行了区分.
在DCIS中,KRT15与病理等级负相关.
在DCIS-MI中,KRT15与雌激素受体状态正相关,与Ki-67.7负相关.
在IBC中,KRT15显示了与HER2阳性,组织学等级和瘤阶段的负相关性.

结论:

乳腺癌不同阶段的KRT15表达模式不同,这表明它作为生物标记物的潜力.
评估KRT15可能有助于早期查和诊断乳腺癌.

关键词:

在KRT15中,KRT15是KRT15.区分能力区分能力区分能力管道癌 in situ 的情况.管道癌在现场与微侵袭.侵袭性乳腺癌是一种侵袭性乳腺癌.

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