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在休息阶段食会导致胃肠道功能障碍,并使大鼠的代谢和神经节律失调

Roberto C Salgado-Delgado¹, Ricardo Espinosa-Tanguma², Belkis Valdés Abadía²

¹Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.

Neurogastroenterology and motility

|October 10, 2023

概括

将食物摄入量限制在休息阶段会扰乱昼夜节律,改变肠道荷尔蒙,胃排空和运动. 这突出了食物的时间.

科学领域:

时间生物学时间生物学
胃肠病学胃肠病学
神经科学是一个神经科学.

背景情况:

由于轮班工作或衰老而扰乱的昼夜节律,会对脑肠轴产生负面影响.
这种干扰有助于胃肠道疾病,如IBS和IBD.

研究的目的:

为了研究在休息阶段限制食对大鼠胃肠功能的影响.
评估对时钟基因表达,肠道荷尔蒙和神经活动的影响.

主要方法:

鼠只在休息阶段被食4周.
评估了胃排空,肠道运动,时钟基因表达,肠道激素分泌和NTS,AP和DMV中的神经活动.

主要成果:

食物限制改变了代谢和昼夜调节转录的表达.
在NTS,AP和DMV中,肠道激素的分泌,胃排空,肠道运动和神经活动发生了显著的改变.

结论:

摄入食物的时间对于调节能量平衡和胃肠内分泌活动至关重要.
食物作为一个强大的昼夜同步器,影响胃肠道和代谢健康.
结果表明,通过操纵食时间,肥胖和肠道疾病的潜在治疗标.

关键词:

昼夜节律是指昼夜节律的节奏.胃肠道的运动性.黑激素是什么意思黑激素是什么意思限制食物获取的限制阴道阴道神经电路.

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