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帕尔马丁通过PI3K/Akt/NF-κB通路减轻LPS诱导的神经炎症

Jianning Zeng¹, Hongyan Pei¹, Hong Wu¹

¹Department of Agriculture and Rural Affairs of Jilin Province Pharmacy and Pharmaceutical Science and Technology, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin, China.

Journal of biochemical and molecular toxicology

|October 10, 2023

概括

来自黄的Palmatine通过调节PI3K/Akt/NFkB通路来有效治疗神经炎症. 这种传统医学可以改善动物模型的学习,记忆和焦虑行为.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

神经炎症是一种复杂的疾病,与各种神经系统疾病有关.
识别有效的治疗剂及其机制对于治疗神经炎症至关重要.
黄的类化合物帕尔马丁 (Palmatine) 显示出神经炎症治疗的潜力.

研究的目的:

研究棕在治疗神经炎症中的分子机制.
探索PI3K/Akt/NFkB信号通路在棕树的作用中的作用.
为了验证palmatine的疗效,使用体外和体内模型.

主要方法:

网络药理学和分子对接确定了palmatine及其相关途径.
分子动力学 (MD) 模拟评估了与乙胆酶的相互作用.
神经炎症的动物模型 (LPS诱导) 用于行为和组织学分析.

主要成果:

帕尔马丁在神经炎症小鼠的学习,记忆和焦虑行为中显著改善.
组织学分析显示,在棕治疗后,大脑损伤和亡减少.
帕尔马丁调节血清炎症因子 (TNF-α,IL-6,IL-1β) 和海马生物化学标志物.
西方斑点证实了palmatine通过激活PI3K/Akt/NFkB通路来改善神经炎症.

结论:

帕尔马具有显著的神经保护和抗神经炎症作用.
PI3K/Akt/NFkB信号通路是帕尔马丁治疗作用的关键目标.
帕尔马丁代表了神经炎症疾病的有前途的治疗药物.

关键词:

在LPS的神经炎症.在PI3K/AKT/NFkBB中使用.血脑屏障是什么意思分子动力学模拟的模拟.

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