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周围血液淋巴细胞对多种癌症预后的影响

Xiaofang Zhang^1,2,3, Jiexian Jing^1,2,3

¹Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Taiyuan, China.

Cancer control : journal of the Moffitt Cancer Center

|October 10, 2023

概括

周围血液的淋巴细胞水平会影响癌症的预后. 保持免疫平衡,特别是CD19+细胞,对于在八种癌症类型中获得更好的患者结果至关重要.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
医学统计医学统计

背景情况:

周围血液淋巴细胞功能在癌症免疫治疗中越来越重要.
淋巴细胞在癌症中的预后作用仍在争论中.
这项研究调查了外周血液淋巴细胞在八种癌症类型的预后意义.

研究的目的:

为了评估外周血液淋巴细胞子集在八种不同的癌症类型的预后影响.
确定免疫细胞平衡与患者存活率之间的关系.
确定影响癌症患者整体生存的关键淋巴细胞子集.

主要方法:

对32,731名癌症患者 (2012-2016) 的回顾性分析.
流细胞计用于量化CD3+,CD4+,CD8+,CD19+,CD56+和CD127+淋巴细胞.
免疫细胞亚群分类的K-平均集群;生存分析的Kaplan-Meier和Cox回归.

主要成果:

在八种癌症类型中,平均存活时间各不相同.
周围血液中的免疫细胞平衡与最有利的预后相关.
在研究的癌症中,CD19+淋巴细胞对整体存活率产生了最显著的影响.

结论:

淋巴细胞透密度与癌症的发展有关.
免疫平衡作为癌症患者潜在的预后指标.
免疫状况评估可以帮助判断癌症治疗的疗效.

关键词:

癌症癌症癌症癌症癌症流动细胞计量是流动细胞计量的方法.淋巴细胞的透透.预后预后预后生存分析,生存分析.

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