将心血管风险与男性雌激素水平联系起来
Ia A Orlova1, E D Sorokin2, Z Sh Pavlova3
1Medical Research and Educational Center, Lomonosov Moscow State University, Moscow; School of Fundamental Medicine, Lomonosov Moscow State University, Moscow.
Kardiologiia
|October 10, 2023
概括
在年轻至中年男性中,高雌激素 (HE) 显著增加了患动脉高血压的可能性. 然而,整体心血管疾病风险评分在具有和没有HE的男性之间没有差异.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 男人的健康 男人的健康
背景情况:
- 血清雌激醇水平升高,称为高雌激素症 (HE) 的情况,在男性中越来越多地被识别出来.
- 在年轻和中年男性中,HE与心血管风险因素之间的关联需要进一步研究.
研究的目的:
- 调查年轻和中年男性心血管风险和雌激素水平之间的关系.
- 确定HE是否与特定的心血管风险因素和整体心血管疾病风险有关.
主要方法:
- 一组71名新诊断出HE的男性 (血清雌激醇>41.2 pg/mL) 与68名年龄和体重指数 (BWI) 匹配的对照组进行了比较,对照组的雌激醇水平正常.
- 测量包括人体测量,生物阻抗,血压 (BP),以及雌激醇,,葡萄糖和总胆固醇的血清度.
- 使用SCORE等级评估了动脉高血压的概率和整体心血管风险.
主要成果:
- 与对照人群相比,患有HE的男性表现出明显较低的丸激素水平 (p=0.006) 和较高的静缩 (p=0.011) 和静缩 (p=0.008) 血压.
- 在HE组中,总胆固醇水平也明显较高 (p=0.023).
- 发现高雌激素是独立的预测因素,使动脉高血压的可能性增加了2.11倍 (p=0.038).
结论:
- 在年轻和中年男性中,高雌激素是动脉高血压的独立预测因子.
- 尽管与高血压和胆固醇变化有关,但SCORE尺度计算的整体心血管疾病风险在各组之间没有显著差异.
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