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三级纳米复合物增强了 lysophosphatidic 酸对人类骨质母细胞 (MG63) 成熟的作用

Hoda Elkhenany¹, Mohamed Abd Elkodous², Jason Peter Mansell³

¹Department of Surgery, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 22785, Egypt.

Nanomedicine (London, England)

|October 10, 2023

概括

当与EB1089和FHBP结合使用时,Ternary纳米复合材料 (TNC) 会增强骨质细胞成熟. 这表明TNC在骨再生应用中是FHBP的有希望的载体.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
整形外科整形外科整形外科

背景情况:

骨质细胞成熟对于骨再生至关重要.
需要新的载体来改善EB1089-(3S) 1--3-基-4-(oleoyloxy) 丁-1-酸盐 (FHBP) 等治疗剂的输送.
三级纳米复合材料 (TNC) 具有增强药物递送和组织再生的潜力.

研究的目的:

调查三元纳米复合材料 (TNC) 在支持MG63骨质细胞成熟的有效性.
评估TNC与EB1089和FHBP联合治疗对骨质母细胞分化的协同效应.
评估TNC作为FHBP在骨再生中的载体的潜力.

主要方法:

制备一个二元纳米复合材料 (P25/减少的石墨烯氧化物[rGO]) 并随后加载银 (Ag) 纳米粒子形成TNC (P25/rGO/Ag).
对TNC对MG63细胞增殖,性酸酶活性和骨质基因表达的影响的评估.
在TNC的存在下,对用EB1089和FHBP进行辅助刺激的MG63细胞的评估.

主要成果:

在MG63骨质母细胞上,TNC没有表现出细胞毒性作用.
除了EB1089-FHBP联合治疗外,TNC还显著增强了MG63骨质细胞的成熟.
随着TNC的联合治疗,观察到性酸酶活性增加和上调的OPN和OCN基因表达.

结论:

三级纳米复合材料 (TNC) 在增强骨质细胞成熟方面显示出显著的潜力.
TNC可以作为FHBP的有效载体,改善其治疗效果.
这些发现表明,TNC-FHBP系统在骨再生疗法中的应用很有前途.

关键词:

骨再生骨再生药物输送是药物输送的过程.骨质母细胞成熟的过程减少的石墨烯减少了石墨烯.二氧化纳米颗粒的二氧化.

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