关于IgE介导食物过敏的诊断EAACI指南
Alexandra F Santos1,2,3, Carmen Riggioni4, Ioana Agache5
1Department of Women and Children's Health (Pediatric Allergy), Faculty of Life Sciences and Medicine, School of Life Course Sciences, King's College London, London, UK.
Allergy
|October 10, 2023
概括
诊断IgE介导的食物过敏包括临床病史,IgE敏感性测试 (如sIgE和SPT),以及潜在的组件解决诊断. 口服食物挑战在不确定的情况下证实了诊断.
科学领域:
- 过敏和临床免疫学
- 诊断医学 诊断医学 诊断医学
背景情况:
- 准确诊断IgE介导的食物过敏对于患者管理至关重要.
- 现有的诊断方法在不同食物的有效性上有所不同.
研究的目的:
- 为诊断IgE介导的食物过敏提供基于证据的建议.
- 为了指导临床医生选择适当的诊断测试.
主要方法:
- 使用了推,评估,开发和评估 (GRADE) 的评级方法.
- 审查了临床病史,血清过敏原特异性IgE (sIgE),皮肤刺伤测试 (SPT),基细胞激活测试 (BAT) 和组件解决的诊断.
- 被认为是口服食品挑战 (OFC) 的参考标准.
主要成果:
- SPT和血清sIgE在诊断花生和果仁过敏方面得到了很好的支持.
- 对小麦和大豆过敏的诊断测试性能较差.
- 过敏原成分sIgE有助于诊断,特别是在对花粉敏感的人群中.
- 可用于花生和芝麻过敏的BAT.
- OFC是对模两可的案件的参考标准.
结论:
- 建议采用多方面的方法,结合临床病史和敏感化测试.
- 过敏原成分测试和BAT提供额外的诊断价值.
- 定期重新评估允许在患有耐受症的儿童中重新引入食物.
相关概念视频
02:06Allergic Reactions
27.6K
Overview
27.6K
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
313
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
313
01:27Allergic Drug Reactions
870
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
870
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
339
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
339
01:10Antibody Structure
60.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.2K