在胚胎植入的时候,非腔腔扭曲的内膜纤维瘤是否会影响子宫内膜?
Haiyan Yang1, Xiaoyan Chen2, Yingyu Liu2
1Hysteroscopic Center, Fu-Xing Hospital, Capital Medical University, Beijing, China.
Human fertility (Cambridge, England)
|October 10, 2023
概括
非腔腔扭曲的内壁纤维瘤可能会改变子宫内膜中Mucin1的表达. 这项研究研究了子宫内膜的变化,发现女性有纤维化腺瘤增加了Mucin1,但其对植入的影响仍然不确定.
科学领域:
- 生殖生物学 生殖生物学
- 妇科 妇科医生 妇科
- 内分泌学 在内分泌学.
背景情况:
- 没有扭曲子宫腔的宫内纤维瘤对生育能力的影响受到争论.
- 了解子宫内膜变化对于评估植入潜力至关重要.
研究的目的:
- 为了研究非腔腔扭曲的内膜纤维瘤对子宫内膜的影响.
- 为了比较纤维瘤受影响和未受影响区域之间的子宫内膜标记物.
主要方法:
- 包括56名患有非腔腔扭曲肌内纤维瘤的妇女.
- 双对子宫内膜样本 (两侧和两侧) 收集在黄激素激增后.
- 分析了组织学约会,Mucin1,Glycodelin表达和子宫自然杀手 (uNK) 细胞密度.
主要成果:
- 与相反侧面相比,ipsilateral光上皮质中的mucin1表达显著更高 (p < 0.05).
- 在腺体Mucin1表达,甘氨酸表达,uNK细胞密度或组织学约会方面没有发现显著差异.
- 在双侧光上皮质中,Mucin1的H评分中位数为210% (142-230%),而在逆侧子宫内膜中为157% (114-176%).
结论:
- 在子宫内膜的光上皮质中Mucin1表达的改变与非腔腔扭曲的内壁纤维瘤有关.
- 在没有其他变化的情况下,在植入时这种Mucin1变化的临床意义需要进一步调查.
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