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Updated: Jul 14, 2025

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改变SIX1-Q177R的结合亲和力与威尔姆斯瘤中增强的WNT5A和WNT通路效应体表达相关

Matthew J Stevenson1, Sabrina K Phanor2, Urvi Patel1

  • 1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Disease models & mechanisms
|October 10, 2023
PubMed
概括

威尔姆斯瘤中的SIX1/2-Q177R突变可以调节WNT5A,这是一种与瘤进展和复发相关的基因. 这种突变增强了SIX1与WNT5A调节区域的结合,导致WNT5A的表达增加.

关键词:
基因调节 基因调节的发育 的发育第六百一十一章 六一在WNT信号传输中.威尔姆斯瘤是一种瘤.

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