接种COVID-19疫苗后的Graves病:一个基于人口的匹配病例控制研究
Alexander Gorshtein1,2, Adi Turjeman2,3, Hadar Duskin-Bitan1,2
1Endocrine Institute, Rabin Medical Center-Beilinson Hospital, Petach Tikva, 4941492, Israel.
The Journal of clinical endocrinology and metabolism
|October 10, 2023
概括
这项研究发现,COVID-19疫苗接种和Graves病发病率之间没有联系. 研究人员分析了2000多名个体的数据,得出结论,接种疫苗不会增加患格雷夫斯病的风险.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 报道显示,2019年冠状病毒病 (COVID-19) 疫苗接种和Graves'病 (GD) 之间可能存在联系.
- 需要进一步的研究来证实或反驳这种关联.
研究的目的:
- 为了确定COVID-19疫苗接种是否与Graves病的发病率增加有关.
- 分析COVID-19疫苗接种和GD诊断之间的时间关系.
主要方法:
- 一项基于人口的,匹配的病例对照研究使用以色列克莱利特医疗服务公司的数据进行.
- 726名在2020年12月至2022年11月期间被诊断患有GD的成年患者与1452名对照进行了匹配.
- 该研究评估了接种疫苗的个体比例和接种疫苗和GD诊断或索引日期之间的时间.
主要成果:
- 在病例和对照群 (80% vs 77.8%) 之间,在接受至少一剂COVID-19疫苗的个体比例中没有发现显著差异.
- 单变量分析显示,COVID-19疫苗接种和GD发病率之间没有关联 (OR 1.15;95% CI .92-1.43).
- 从接种疫苗到GD诊断或索引日期的平均时间在两组中都是相似的.
结论:
- 这项研究没有发现证据支持COVID-19疫苗接种与Graves病发病率之间的关联.
- 这些发现表明,COVID-19疫苗接种不会增加患Graves病的风险.
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