从SARS-CoV-2感染和怀孕期间接种疫苗中分离的孕产妇和带抗体功能
Emily H Adhikari1,2, Pei Lu3, Ye Jin Kang3
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
The Journal of infectious diseases
|October 10, 2023
概括
孕妇接种疫苗和怀孕期间COVID-19感染可以提高婴儿的免疫力. 抗体功能和糖基化是关键的,为保护新生儿提供了新的方法.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇和胎儿的医学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 母亲免疫显著影响婴儿发育,但确切的机制仍然不完全理解.
- 怀孕涉及独特的免疫暴露,包括疫苗接种和像SARS-CoV-2这样的病毒感染,对新生儿免疫有潜在的长期影响.
研究的目的:
- 为了调查mRNA冠状病毒病2019 (COVID-19) 疫苗接种和严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染在怀孕期间对孕产妇和新生儿抗体功能的影响.
- 为了比较疫苗接种,感染及其组合对抗体中和,Fc效应器功能和对母体和带血的糖化作用.
主要方法:
- 对外围母体和带血样本进行对照分析.
- 对抗体功能的评估,包括中和和Fc介导的效应器功能.
- 评估IgG1水平和抗体糖化模式.
主要成果:
- 孕产妇接种疫苗在孕产妇血液中增强了特定的中和和Fc效应的功能,主要由IgG1介导.
- 在带血中,母亲接种疫苗增强了IgG1,优先转移Fc效应器功能而不是中和活动.
- 翻译后IgG糖化酶的变化显著影响了带血中的抗体功能强度,而不是母亲的血液.
- 与单独暴露相比,联合疫苗接种和感染显示出增强的效果.
结论:
- Fc效应函数和抗体糖化是关键的,但尚未被充分研究的,在母婴免疫转移中的因素.
- 孕产妇的免疫暴露提供了增强新生儿免疫力和保护新生儿的机会.
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