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Updated: Jul 14, 2025

04:44
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
324
双极性障碍的诊断和治疗:一篇综述
Andrew A Nierenberg1,2, Bruno Agustini3, Ole Köhler-Forsberg1,4,5,6
1Dauten Family Center for Bipolar Treatment Innovation, Massachusetts General Hospital, Boston.
JAMA
|October 10, 2023
概括
双极性障碍影响全球数以百万计的人, 早期干预和持续治疗对于改善结果和降低死亡风险至关重要.
科学领域:
- 精神病学与神经科学
- 临床心理学
- 公共卫生
背景情况:
- 双极性障碍影响了800万美国成年人和4000万全球成年人,其特点是经常出现抑郁和躁狂/躁狂发作.
- 通常发生在15-25岁之间,抑郁是最常见的初始表现,抑郁症状约占症状时间的75%.
- 延迟诊断,平均9年后初始抑郁情节,是常见的,显著影响预后.
结论:
- 双极性障碍与预期寿命显著减少 (12-14年) 和心血管死亡率增加有关.
- 代谢综合征,肥胖,吸烟和2型糖尿病的高发病率导致过早死亡.
- 年度自杀率大幅上升 (0.9%对比0.014%),15-20%的双相情感障碍患者死于自杀.
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