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基因预测肠道微生物组和口腔癌的风险
Kun Xiang1, Cheng-Xi Li1, Ran Chen2
1Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China.
Cancer causes & control : CCC
|October 10, 2023
概括
根据孟德尔随机化 (MR) 分析,肠道细菌Prevotellaceae可能会增加口腔癌的风险. 这一发现突出了口腔癌预防策略的潜在目标.
科学领域:
- 微生物组研究 微生物组研究
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 新出现的证据表明,肠道微生物和口腔癌之间存在联系.
- 肠道微生物组为口腔癌的预防提供了潜在的可修改的目标.
研究的目的:
- 使用孟德尔随机化 (MR) 调查肠道微生物群和口腔癌之间的潜在因果关系.
主要方法:
- 使用与肠道微生物组相关的单核酸多态 (SNP) 作为仪器变量.
- 执行了MR分析,以逆方差权衡 (IVW) 为主要方法,得到MR Egger和加权中位数的支持.
- 采用MR-PRESSO和MR-Egger回归来评估横向型和识别异常SNP.
主要成果:
- 基因预测Prevotellaceae的丰富性与口腔癌的风险增加显著相关 (OR 1.80,95% CI 1.16-2.81,p=0.009).
- 没有发现异质性或水平质的显著证据.
结论:
- 有基因信息的估计表明,Prevotellaceae可能在口腔癌风险中起作用.
- 需要进一步的研究来探索连接Prevotellaceae和口腔癌的潜在生物机制.
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