Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Sex-linked Disorders01:43

Sex-linked Disorders

102.3K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.3K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

560
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
560
Pedigree Analysis01:35

Pedigree Analysis

84.4K
Overview
84.4K
X-linked Traits01:19

X-linked Traits

55.0K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
55.0K
The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

8.6K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.6K
X and Y Chromosomes02:32

X and Y Chromosomes

26.2K
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
26.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The SINTER study: a recall-by-genotype design with multidimensional musculoskeletal phenotyping across internal-medicine outpatient clinics.

European journal of epidemiology·2026
Same author

[Bempedoic acid in real-world clinical practice: baseline and 8-week data from the Italian prospective, non-interventional MILOS study].

Giornale italiano di cardiologia (2006)·2026
Same author

Challenges in assessing statin-associated adverse events.

Lancet (London, England)·2026
Same author

LDL receptor-mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10- and FOXP3-driven phenotype.

JCI insight·2026
Same author

Voices of those recruiting: A qualitative study on barriers and enablers to women's participation in cardiovascular trials.

Atherosclerosis·2026
Same author

Familial hypercholesterolaemia in children and adolescents: a European Atherosclerosis Society consensus statement.

European heart journal·2026

相关实验视频

Updated: Jul 14, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.2K

在家族高胆固醇血症中的性别差异

Marianne Klevmoen1,2, Janneke W C M Mulder3, Jeanine E Roeters van Lennep3

  • 1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Current atherosclerosis reports
|October 10, 2023
PubMed
概括

本综述强调了家族性高胆固醇血症 (FH) 的性别差异,并指出女孩和妇女的LDL-C较高,诊断较晚,女性治疗较少,增加心血管风险. 终身,性别特定的管理至关重要.

关键词:
哺乳期 哺乳期 哺乳期心血管疾病是什么心血管疾病胆固醇 胆固醇 胆固醇家庭性高胆固醇血症是什么?怀孕 怀孕 怀孕 怀孕性差异性差异性差异性差异性差异性差异性差异性

更多相关视频

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.5K

相关实验视频

Last Updated: Jul 14, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.2K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.5K

科学领域:

  • 心血管研究研究心血管研究
  • 遗传学与疾病的关系
  • 内分泌学和新陈代谢学

背景情况:

  • 家庭性高胆固醇血症 (FH) 是一种遗传性疾病,导致高的LDL-C水平.
  • 在FH诊断和管理方面,越来越多地认识到基于性别的差异.
  • 了解FH终身性别差异对于心血管健康至关重要.

研究的目的:

  • 审查现有的关于家族高胆固醇血症 (FH) 生涯性差异的研究.
  • 为了确定胆固醇水平,诊断和治疗的性别特异性模式.
  • 突出女性生命阶段对FH管理和心血管风险的影响.

主要方法:

  • 对FH性别差异研究的系统文献综述.
  • 对脂质水平,诊断年龄和按性别遵守治疗的数据进行分析.
  • 综合与男性和女性FH患者心血管疾病风险相关的发现.

主要成果:

  • 患有FH的女孩的LDL-C比童年时的男孩高.
  • 女性在30岁时体验到更大的LDL-C负担,并且比男性晚诊断.
  • 女性FH患者接受的降脂治疗较少,导致较高的LDL-C和心血管风险增加,特别是在怀孕和母乳养期间.

结论:

  • 对于患有FH的女孩和妇女来说,早期和终身的,性别特定的治疗启动至关重要.
  • 未来的研究必须报告性别特异性数据,并调查女性生命历程的影响.
  • 准则应纳入性别特异性考虑,以实现最佳的FH管理和心血管结果.