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吉富林可以通过阻断MAPK14/FOXO3A信号通路来缓解败血症

Yi Wang¹, Ming-Qi Chen², Lin-Feng Dai²

¹Department of Critical Care Medicine, Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Changzhou, Jiangsu Province, 213000, China.

Chinese journal of integrative medicine

|October 10, 2023

概括

花 (Fangji Fuling Decoction,简称FFD) 通过抑制基因激活蛋白激酶14/叉头盒O3A (MAPK14/FOXO3A) 途径来减少毒症中的器官损伤和炎症. 这项研究将网络药理与体外和体内实验相结合.

科学领域:

药理学药理学是指药理学的学科.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

败血症是一种危及生命的器官功能障碍,是由宿主对感染的反应失调引起的.
脂聚糖 (LPS) 是格拉姆阴性细菌的关键成分,在败血症中触发炎症反应.
传统中医药 (TCM) 配方,如方吉精 (FFD),正在探索其在败血症中的治疗潜力.

研究的目的:

为了研究吉富林 (FFD) 对败血症的治疗效果.
通过网络药理学阐明FFD作用的基础分子机制.
通过体外和体外实验模型验证发现.

主要方法:

在小鼠 (LPS注射) 和RAW264.7巨细胞 (LPS刺激) 中建立了败血症模型.
网络药理学确定了FFD对败血症的行动中涉及的关键途径.
在体外和体内实验中评估了FFD对器官损伤,炎症,细胞亡以及MAPK14/FOXO3A信号通路的影响.

主要成果:

在LPS诱导的败血症小鼠中,FFD显著降低了器官损伤和炎症.
在体外,FFD抑制了LPS诱导的巨细胞亡和炎症.
网络药理学和实验验证证证实,FFD抑制了MAPK14/FOXO3A信号通路,减轻了败血症引起的炎症和亡.

结论:

在改善败血症方面,FFD显示出治疗潜力.
抑制MAPK14/FOXO3A信号通路是FFD在败血症中发挥抗炎和抗亡作用的关键机制.
FFD为管理与败血症相关的炎症反应提供了一个有希望的治疗策略.

关键词:

中国医学中医药是什么?方吉富林精液 - - 精液灭症 (apoptosis) 是一种死亡的过程.炎症反应是一种炎症反应.肺部受伤的原因是肺部损伤.线素激活蛋白激酶14/叉头盒O 3A信号通路的信号通路这是一种血症.

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