高海拔低氧对神经精神功能的影响
Bo Liu1,2, Minlan Yuan1, Mei Yang3
1Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, China.
High altitude medicine & biology
|October 10, 2023
概括
高海拔低氧会导致严重的大脑问题,影响神经和精神功能. 需要更多的研究来了解机制,并开发有效的治疗方法,这些与高度相关的条件.
科学领域:
- 神经科学是一个神经科学.
- 高度医学 高度医学
- 精神病学是一个精神病学.
背景情况:
- 高海拔活动越来越受欢迎,但会使个人暴露在缺氧中.
- 高海拔地区的缺氧会导致急性或慢性脑疾病,包括神经和精神疾病.
- 关于与高度相关的神经精神疾病及其机制的现有文献评论很少.
研究的目的:
- 要总结由高度缺氧引起的普遍神经精神疾病.
- 探索潜在的病理生理机制,这些条件的基础.
- 审查与高度相关的神经精神病影响的可用预防和干预策略.
主要方法:
- 在PubMed和谷歌学者上进行文献搜索.
- 包括临床前和临床研究.
- 专注于总结疾病,机制和干预措施.
主要成果:
- 高度低氧可以诱导各种神经疾病,如急性山病 (AMS),脑和脑血管疾病.
- 精神疾病如焦虑,抑郁和精神病也与高空暴露有关.
- 致病过程包括神经血管变化,细胞毒性反应,氧化应激,以及HIF-1和Nrf2的失调.
结论:
- 由于缺氧导致的神经精神病变化的确切机制尚不清楚.
- 目前的预防和干预策略主要针对AMS,重点是预防而不是治疗.
- 需要进一步的研究来阐明机制,并开发与高度相关的神经精神疾病的综合治疗方法.
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