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Updated: Jun 13, 2026

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在状细胞疾病中改变疼痛处理和敏感化:对定量感官测试结果的范围审查

Martha O Kenney1, Mitchell R Knisely2, Lakeya S McGill3

  • 1Division of Pediatric Anesthesiology, Department of Anesthesiology, Duke University, Durham, NC 27710, United States.

Pain medicine (Malden, Mass.)
|October 10, 2023
PubMed
概括

在状细胞疾病 (SCD) 中,定量感官测试 (QST) 揭示了各种方法和感官异常的证据,包括改变的疼痛值. 需要标准化的QST协议来理解SCD中的慢性疼痛机制.

关键词:
中央敏感化中心慢性疼痛是一种慢性疼痛.定量感官测试 定量感官测试 定量感官测试状细胞疾病是一种状细胞疾病.

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...