神经控制肠道修复的神经控制
1Science Signaling, AAAS, Washington, DC 20005, USA.
Science signaling
|October 10, 2023
概括
肠道损伤会触发特定神经细胞的生长,称为上腺神经元. 这些神经元激活了一条促进肠道组织修复和再生的途径.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 再生医学是一种再生医学.
背景情况:
- 肠道损伤可能导致严重的组织损伤和功能障碍.
- 神经系统,特别是上腺神经元在肠道修复中的作用尚未完全理解.
研究的目的:
- 研究上腺神经元在肠道损伤后的再生反应中的作用.
- 为了确定由这些神经元刺激的前再生途径.
主要方法:
- 使用了小鼠肠道损伤模型.
- 采用了免疫组织化学和基因表达分析等技术.
- 研究了神经元外生和信号通路.
主要成果:
- 在受伤的肠道组织中显示出上腺神经元的显著增长.
- 表明这些神经元刺激了一条对修复至关重要的前再生途径.
- 确定了参与这个过程的特定分子介质.
结论:
- 上腺神经元在受伤后促进肠道再生方面发挥着至关重要的作用.
- 准这种神经元通路可能为肠道愈合提供新的治疗策略.
相关概念视频
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Enteric Nervous System: Regulation of GI Motor Activity
411
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
411
Physiology of Enteric Nervous System and Gut Health
281
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
281
Nerve Supply of the GI Tract
1.4K
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
1.4K
Neurogenesis and Regeneration of Nervous Tissue
836
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
836
Regulation of the Digestive System
629
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
The effectors in this regulation system are glands and smooth muscles. Activation of...
629


