可按需注射的脉冲性药物输送水凝使用交替磁场触发的聚合物玻璃过渡
Scott Campbell1, Nahieli Preciado Rivera1, Somiraa Said1,2
1Department of Chemical Engineering, McMaster University, 1280 Main St. W., Hamilton L8S 4L7, Ontario, Canada.
ACS applied materials & interfaces
|October 10, 2023
概括
带有磁纳米颗粒的可注射水凝提供精确的远程药物输送. 这种微创系统可以实现高级治疗治疗的高开/关释放率.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 目前的遥控药物释放系统缺乏精度,需要进行手术植入.
- 在州内和州外的药物释放之间实现高分辨率仍然是一个挑战.
研究的目的:
- 开发一种可注射,遥控的药物输送器,具有高开/关释放分辨率.
- 为了克服手术植入和低释放控制在当前系统中的局限性.
主要方法:
- 用一种模型药物和接近生理温度的玻璃过渡温度 (Tg) 装载的聚合物纳米粒子 (p(MMA-co-BMA)) 的制造.
- 在可注射水凝基质中,与超偏磁性氧化铁纳米粒子 (SPIONs) 共同封装载有药物的纳米粒子.
- 药物释放的远程激活使用交替磁场 (AMF) 进行受控加热.
主要成果:
- 开发的纳米复合物水凝展示了可调节的药物释放动力学.
- 通过在37°C和45°C之间进行温度循环,实现了2.5:1到6:1的开/关释放比.
- 在AMF暴露后观察到增强的药物释放,甚至在注射后一周,具有良好的细胞相容性.
结论:
- 可注射纳米复合物水凝为远程控制药物输送提供了一个有希望的微创方法.
- 该系统具有高开关释放分辨率和持续的功能,适合复杂的治疗策略.
关键词:
基甲基酸丁的使用方法有控制释放的释放.玻璃过渡温度是玻璃过渡温度.可以注射的水凝.铁氧化物纳米粒子 铁氧化物纳米粒子甲基甲基烯酸甲酸甲基甲基烯酸甲酸甲基甲基烯酸甲酸甲基甲基烯酸甲基烯酸甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲按需提供药物交付服务.更多相关视频
08:39Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
Published on: July 4, 2017
9.0K
08:17An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
Published on: July 18, 2018
7.2K
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...