在患有神经纤维肌瘤症的患者中精神病并发症的患病率
Kanwarjeet S Brar1,2, Chintan Trivedi3, Navdeep Kaur4
1Mindpath Health, Manteca, California.
The primary care companion for CNS disorders
|October 10, 2023
概括
几乎一半的成年神经纤维素瘤患者患有精神病并发症,主要是情绪和焦虑障碍. 女性性别和非白人种族与较低的并发病率有关.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 神经纤维素瘤 (NF) 是一组遗传性疾病,其特点是神经系统中瘤的发展.
- 在NF患者中经常观察到精神病并发症,影响其生活质量和治疗管理.
- 了解这些并发症的患病率和模式对于全面的患者护理至关重要.
研究的目的:
- 确定诊断为神经纤维素瘤病的成年患者中精神病并发症的患病率.
- 为了确定这个患者群体中最常见的特定精神疾病.
- 探索与神经纤维素瘤病的精神病并发症存在相关的人口和临床因素.
主要方法:
- 使用2010-2014年国家住院患者样本数据库进行的横截面研究.
- 纳入标准:年龄在18岁或以上,初级或二级诊断为神经纤维素瘤病的患者.
- 数据分析的重点是识别精神病并发症和相关的人口和临床变量.
主要成果:
- 总共分析了43.270名患有神经纤维素瘤症的成年患者.
- 精神病并发症在46.5%的患者中存在,其中情绪障碍 (22.1%) 和焦虑障碍 (12.2%) 是最常见的.
- 女性性别和非白人种族与精神病并发症的可能性较低有关 (分别为OR=0.868,P=.003和OR=0.689,P<.001).
- 较高的疾病严重程度 (中度至极度的功能丧失) 与精神病并发症的几率增加相关 (OR=1.35,P<.001).
- 注意力缺陷/多动症的患病率低于之前报告的 (1.10%).
结论:
- 显著比例的成年神经纤维素瘤患者经历精神伴随性疾病,强调了综合心理健康查和护理的需要.
- 情绪和焦虑障碍是与神经纤维化相关的最常见的精神疾病.
- 女性性别和非白人种族等人口统计因素似乎对这一群体的精神病并发症有保护作用,而更大的功能障碍增加了风险.
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