静脉血栓栓塞和含有雌激素的性别确认激素治疗
Caroline Dix1, Mollie Moloney2, Huyen A Tran1,2
1Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia.
Thrombosis and haemostasis
|October 10, 2023
概括
跨性别女性的性别肯定激素治疗 (GAHT) 可能会带来静脉血栓塞栓症 (VTE) 的风险,尽管现代治疗更安全. 需要进一步的研究,以充分了解和减轻这一群体的VTE风险.
科学领域:
- 内分泌学 在内分泌学.
- 血管医学 血管医学
- 跨性别者健康 跨性别者健康
背景情况:
- 性别确认激素治疗 (GAHT) 使用激素使身体特征与性别认同保持一致.
- 静脉血栓塞栓症 (VTE) 是一种与外源性雌激素治疗相关的已知的风险.
- 虽然有证据正在出现,但高达5%的跨性别女性可能会经历现代GAHT的VTE.
研究的目的:
- 对接受雌激醇GAHT的跨性别女性VTE风险的现有文献进行审查.
- 为了检查雌激醇给药途径对静脉瘤风险的影响.
- 讨论GAHT治疗青少年的GAHT和VTE风险的术后管理.
主要方法:
- 对VTE风险和GAHT研究的文献综述.
- 对雌醇制剂,剂量和使用途径的分析.
- 在跨性别人群中检查VTE风险因素.
主要成果:
- 从历史上看,GAHT具有较高的VTE风险,但现代制剂使用较低的剂量,并且具有较低的血栓发生率.
- 雌激素的使用途径显著影响了静脉瘤风险.
- 在GAHT的青少年中,关于VTE风险的数据是有限的.
结论:
- 与历史治疗相比,现代的GAHT与较低的VTE风险有关.
- 进一步的大型纵向研究对于鉴定 GAHT 变性女性的 VTE 风险因素至关重要.
- 更好的理解可以为跨性别者医疗保健的临床指南提供信息.
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