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较低的生长激素分泌与急性后续的SARS-CoV-2感染 (PASC) 神经症状相关:一个病例控制试点研究

Traver J Wright¹, Richard B Pyles², Melinda Sheffield-Moore¹

¹Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, 77555, USA.

Molecular and cellular endocrinology

|October 10, 2023

概括

在COVID-19之后,持续的疲劳和脑雾可能与低生长激素 (GH) 分泌有关. 这项研究表明,SARS-CoV-2 (PASC) 后急性后续会破坏GH,影响患者的康复.

科学领域:

内分泌学在内分泌学.
神经学神经学
传染性疾病传染性疾病

背景情况:

SARS-CoV-2 (PASC) 后急性后果可能会导致持续的神经症状,如疲劳和"脑雾".
其他疾病的类似症状有时与生长激素 (GH) 缺乏有关.

研究的目的:

调查PASC患者是否表现出减少GH分泌的情况.
为了比较PASC患者的神经症状,神经认知和GH分泌与康复的对照.

主要方法:

一项病例控制试点研究比较了10名PASC患者和13名非PASCCOVID-19幸存者.
评估血液化学,荷尔蒙,炎症标志物和维生素.
通过测试和问卷评估神经认知,GH分泌,耐葡萄糖和上腺功能.

主要成果:

帕斯克患者报告说,疲劳,睡眠,抑郁,生活质量和胃肠道不适变得更糟.
认知测试显示,尽管自我报告的认知问题,但没有显著的群体差异.
神经性PASC症状与减少GH分泌相关,而不是炎症或上腺问题.

结论:

在PASC中的神经症状与胃肠道不适有关.
持续破坏GH分泌与COVID-19康复后的神经 PASC 症状有关.

关键词:

生物标志物生物标志物认知认知是一种认知.抑郁症抑郁症抑郁症疲劳疲劳疲劳疲劳疲劳胃肠道胃肠道胃肠道生长激素生长激素的作用长时间的COVID.帕斯克 (Pasc) 是一个过去.生活质量生活的质量.这就是SARS-CoV-2病毒.睡眠睡眠睡眠睡眠

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