近视性冠状腺新血管化的复发风险:对当前研究的系统审查
Andi Arus Victor1, Gitalisa Andayani2, Ari Djatikusumo2
1Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia arvimadao@yahoo.com.
BMJ open ophthalmology
|October 10, 2023
概括
鉴定近视性冠状腺新血管化 (m-CNV) 复发的危险因素对于改善患者的治疗结果至关重要. 关键因素包括注射频率,年龄,病变大小和视网膜的结构变化.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 新血管化的新血管化.
背景情况:
- 近视性冠状腺新血管化 (m-CNV) 在眼科中是一个重大挑战,原因是其高复发率和不令人满意的长期结果.
- 有效的管理策略受到缺乏对复发预测因素的全面理解的阻碍.
研究的目的:
- 系统地审查和识别与近视性冠状腺新血管化 (m-CNV) 复发相关的关键风险因素.
- 为具有高m-CNV复发风险的患者提供个性化治疗策略和主动管理的信息.
主要方法:
- 根据预先注册的协议 (PROSPERO CRD4202343461) 进行了全面的系统审查.
- 在主要数据库 (PubMed,Cochrane Library,Embase,Scopus,ScienceDirect) 中使用相关的关键词进行了搜索.
- 包括三个回顾性研究,并分析了m-CNV复发的风险因素.
主要成果:
- 确定了m-CNV复发的危险因素包括:需要多次注射进行初始控制,年龄较大,神经血管病变大小较大,正侧面位置,超反射焦点 (HRF) 的高度增加,圆形区域 (EZ) 和视网膜色素上皮质 (RPE) 的结构损伤.
结论:
- 几种临床和成像因素显著增加了m-CNV复发的风险.
- 了解这些预测因素可以定制治疗方法和改善患者管理.
- 需要进一步的研究来阐明潜在的机制,并开发新的治疗干预措施.
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