半参数正常转换联合模型的多变量纵向和双变量时间到事件数据
An-Ming Tang1, Cheng Peng1, Niansheng Tang1
1Yunnan Key Laboratory of Statistical Modeling and Data Analysis, Yunnan University, Yunnan, People's Republic of China.
Statistics in medicine
|October 10, 2023
概括
这项研究引入了一种新的纵向和生存数据的联合模型,处理临床试验中常见的相关生存数据. 贝叶斯适应拉索方法同时估计参数并选择预测因子,以改进分析.
科学领域:
- 生物统计学 生物统计学
- 临床试验方法论 临床试验方法论
- 生存分析的分析.
背景情况:
- 纵向和生存数据 (JMLSs) 的联合模型对于分析临床试验数据至关重要.
- 现有的JMLS通常假定独立的生存数据,这是限制性的.
- 在临床环境中经常观察到生存数据的两变相关性.
研究的目的:
- 提出一个新的JMLS,容纳多变量纵向和双变量相关的时间到事件数据.
- 开发一个强大的统计框架来分析复杂的临床试验数据结构.
- 为了增强与相关生存结果的JMLS中的预测因素选择和参数估计.
主要方法:
- 非参数边际生存危险函数转换为双变量正常随机变量.
- 使用贝叶斯惩罚线来近似未知基线危险函数.
- 采用贝叶斯适应拉索方法,将大都会-哈斯廷斯集成到吉布斯采样器中,用于同时估计,危险函数近似和预测器选择.
主要成果:
- 拟议的JMLS有效地处理多变量纵向和双变量相关的时间到事件数据.
- 贝叶斯自适应拉索方法证明了同时进行参数估计,基线危险函数估计和重要的预测因素选择.
- 通过模拟研究和国际乳腺癌研究小组的现实实例验证的方法.
结论:
- 新的JMLS为分析临床试验中复杂的纵向和相关生存数据提供了一个强大的工具.
- 开发的贝叶斯适应拉索方法为估计和变量选择提供了全面的方法.
- 这种方法提升了临床试验数据的分析,特别是在处理相关生存结果时.
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