每天用利托纳维尔增强的达鲁纳维尔用于妊娠中的病毒抑制 (DRV-P)
Nikolina Gacic1, Karen Tulloch1,2,3,4, Deborah Money1,2,3
1Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada.
HIV medicine
|October 10, 2023
概括
利托纳维尔增强达鲁纳维尔 (DRV/r) 每天800/100毫克对艾滋病毒感染的孕妇有效,保持病毒抑制,没有垂直传播. 坚持度很高,治疗方案耐受性很好.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 里托纳维尔增强达鲁纳维尔 (DRV/r) 是艾滋病毒感染孕妇的首选抗逆转录病毒药物.
- 目前在不列颠哥伦比亚省的临床实践在整个怀孕期间使用每天800/100毫克的DRV/r剂量.
- 一些指导方针建议每天两次 (600/100毫克) 治疗方案,因为怀孕期间可能发生药理动力学变化.
研究的目的:
- 评估艾滋病毒感染的孕妇每天服用一次DRV/r (800/100毫克) 的疗效和安全性.
- 评估病毒抑制率,垂直艾滋病毒传播风险,药物不良影响和患者坚持治疗.
- 在这个人群中为DRV/r提供最佳剂量策略.
主要方法:
- 在不列颠哥伦比亚省感染艾滋病毒的孕妇的回顾性分析.
- 纳入标准:2015年1月至2021年8月间分娩,并在怀孕期间每天接受DRV/r 800/100毫克的妇女.
- 收集关于病毒载量,传播,不良事件和坚持的数据.
主要成果:
- 这项研究包括34名女性.
- 在三个月内观察到高水平的病毒抑制 (100%在第一,75%在第二,74%在第三).
- 没有报告垂直艾滋病毒传播病例;该疗法耐受性良好,坚持高 (>75%).
结论:
- 每天服用一次以里托纳维尔增强达鲁纳维尔 (800/100毫克) 是适合HIV感染的孕妇使用的剂量策略.
- 这种疗法支持病毒抑制,并防止垂直传播,当保持最佳的坚持.
- 这些发现支持了树诊所目前在怀孕期间使用DRV/r剂量的临床实践.
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