用ProHarMeD进行蛋白质基因元研究协调,机型化和药物重定位候选预测
Klaudia Adamowicz1, Lis Arend1, Andreas Maier1
1Institute for Computational Systems Biology, University of Hamburg, Hamburg, 22607, Germany.
NPJ systems biology and applications
|October 10, 2023
概括
ProHarMeD协调了多样化的蛋白质组学数据,使生物标志物发现和药物重新使用成为可能. 该工具整合了不同生物体和测试的研究,揭示了疾病机制和潜在的治疗候选者.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 蛋白质组学技术对于识别生物标志物和疾病机制至关重要.
- 目前公开的蛋白质组学数据在研究中分散,阻碍了整合和分析.
- 非协调的标识符和各种实验系统阻碍了元分析和数据整合.
研究的目的:
- 介绍ProHarMeD,这是一个协调和比较多项研究蛋白质组学数据的工具.
- 为了促进疾病机制的提取,并确定药物重用候选人.
- 为无数据集成提供一个用户友好的平台 (web,Python,R).
主要方法:
- ProHarMeD在蛋白质和基因水平之间,以及通过ortolog映射在生物体之间执行ID和名称转换.
- 该工具生成了ID转换的详细日志,并识别了跨研究的共享ID.
- 它通过交互式可视化自动提出疾病机制和药物重定向候选人.
主要成果:
- 使用ProHarMeD的ID协调在骨再生数据集中将研究之间的共享基因增加了50%.
- 确定了潜在的疾病机制,以及五种药物标和20种药物重新定位候选药物.
- 一些已确定的候选药物,包括Fondaparinux,已证明对骨再生产生影响.
结论:
- ProHarMeD能够有效地协调多中心蛋白质组学数据,用于元分析.
- 该工具有助于评估ID转换成功,并促进疾病机制挖掘.
- ProHarMeD弥合了蛋白质组学,疾病机制发现和药物重新利用之间的差距.
更多相关视频
08:31Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
5.0K
09:52A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
Published on: January 10, 2025
632
相关概念视频
01:33Proteomics
7.4K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.4K
02:04Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
02:26Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K