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应推BRAF^V600E基因检测贝塞斯达III或V甲状腺结节,以精细针吸收为基础

Yiran Lu¹, Xinghong Guo^1,2,3,4, Mengmeng Yang¹

¹Department of Endocrine and Metabolic Diseases, Qilu Hospital of Shandong University, Jinan, China.

Scientific reports

|October 10, 2023

概括

BRAFV600E遗传检测在与精细针吸收活检 (FNAB) 结合时,可以改善甲状腺结节诊断. 这种测试对贝塞斯达III和V结节最有益,有助于患者的选择.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
遗传学遗传学是一个

背景情况:

精细针吸收活检 (FNAB) 是甲状腺结节评估的标准.
在中国,BRAFV600E基因检测越来越多地用于手术前.
识别BRAFV600E测试的最佳候选人对于有效诊断至关重要.

研究的目的:

为了确定BRAFV600E基因测试与FNAB联合用于甲状腺结节的疗效.
确定特定的患者子组,这些患者将从联合测试中获益最多.

主要方法:

在2019年5月至2021年12月接受FNAB治疗的12,392名患者的回顾性分析.
仅使用FNAB和使用BRAFV600E测试的FNAB之间的恶性瘤发病率的比较.
基于贝塞斯达分类的子组分析.

主要成果:

结合FNAB和BRAFV600E测试显示,与单独使用FNAB (93.12%) 相比,恶性瘤发病率更高 (98.20%).
BRAFV600E测试显著有利于贝塞斯达III (p < 0.001) 和V (p = 0.001) 结节.
总的来说,联合测试改善了手术甲状腺结节恶性瘤检测率.

结论:

结合FNAB和BRAFV600E遗传测试可以提高甲状腺结节的诊断准确度.
BRAFV600E测试对于贝塞斯达III和V结节特别有价值.
这些发现支持在临床实践中对BRAFV600E遗传测试采取更有针对性的方法.

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