人类牛奶寡糖在婴儿期改变了Bifidobacterium社区组合中优先效应的强度
Martin F Laursen1, Henrik M Roager2
1National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark. mfrla@food.dtu.dk.
The ISME journal
|October 10, 2023
概括
Bifidobacterium物种殖民婴儿肠道的顺序影响社区集会. 来自母乳的人类牛奶寡糖 (HMO) 可以取代这些优先效应,促进高效的HMO利用物种的主导地位.
科学领域:
- 微生物学 微生物学
- 生态生态学 生态生态学
- 婴儿健康 婴儿健康
背景情况:
- 肠道微生物群在婴儿的健康和发育中起着至关重要的作用.
- 生态优先效应,即物种到达的时间和顺序影响社区聚集,在婴儿肠道微生物群落中不太了解.
- 双杆菌物种是婴儿肠道的早期殖民者,一些物种擅长利用人乳寡糖化物 (HMO).
研究的目的:
- 调查优先效应在Bifidobacterium社区聚集在婴儿肠道中的作用.
- 为了确定人乳寡糖化物 (HMO) 如何影响Bifidobacterium殖民动态.
- 阐明管理生命早期肠道微生物社区结构的生态过程.
主要方法:
- 在25名母乳养的丹麦婴儿生命前6个月的肠道微生物群的纵向采样.
- 基因生物小鼠模型连续殖民Bifidobacterium longum亚种. 长和Bifidobacterium长子物种. 孩子们的孩子们.
- 在小鼠模型中对HMO可用性的实验操纵.
主要成果:
- 婴儿最初被低于最佳的使用HMO的Bifidobacterium种群所殖民,后者被更高效的使用HMO的种群所取代.
- 在Gnotobiotic小鼠中,殖民秩序确定了在HMO缺席的情况下Bifidobacterium的统治地位.
- 在小鼠中,HMO补充剂减少了优先效应的影响,使高效的HMO使用者能够不受殖民秩序的影响而占主导地位.
结论:
- 双杆菌殖民的顺序和母乳衍生的HMO的可用性是塑造婴儿肠道微生物组的关键因素.
- 优先效应在生命早期的肠道微生物组合中发挥作用,但可以通过特定营养素的可用性来调节.
- 了解这些动态对于促进婴儿肠道健康发育至关重要.
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