在中国东部慢性胰腺炎患者中坚持胰腺酶替代疗法:一项混合方法研究
You Zhou1,2,3, Ren-Qian Huang1, Qi-Wei Wu4
1Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.
Scientific reports
|October 10, 2023
概括
在东中国慢性胰腺炎 (CP) 患者中,胰腺酶替代疗法 (PERT) 的坚持不佳. 诸如教育程度低,收入低,知识不足等因素导致不坚持,需要个性化治疗策略.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 胰腺酶替代疗法 (PERT) 是慢性胰腺炎 (CP) 中胰腺外分泌功能不全的标准治疗方法.
- 影响东中国PERT管理和遵守的患者相关因素尚不清楚.
- 关于特别在中国东部的CP人口中坚持PERT的研究有限.
研究的目的:
- 为了研究在中国东部的CP患者中对PERT的药物坚持 (MA).
- 为了确定与患者相关的因素,与不良的PERT坚持相关.
- 探索这些人群中不遵守PERT背后的原因.
主要方法:
- 一个连续的解释性混合方法研究,结合了定量和定性方法.
- 定量阶段:对148名CP患者的药物坚持 (MA) 的横截面调查.
- 定性阶段:与24名患者进行半结构面试,以探索坚持因素.
主要成果:
- 近一半 (48.0%) 的患者表现出不良的MA,只有12.8%的患者表现出良好的MA.
- 较低的教育水平和收入是不遵守PERT的重要预测因素.
- 定性发现揭示了其他不遵守的原因:知识不足,自我治疗调整,终身治疗,副作用,遗忘,财务压力和可访问性问题.
结论:
- 在中国东部的慢性胰腺炎患者中,PERT的坚持不够理想.
- 医疗保健提供者应实施个性化策略,以提高患者对PERT的坚持.
- 解决知识差距,财务负担和副作用管理对于改善PERT结果至关重要.
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