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与艾滋病毒相关的认知障碍背后的机制及其管理的新兴疗法
Ronald J Ellis1,2, María J Marquine3,4, Marcus Kaul5
1Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. roellis@ucsd.edu.
Nature reviews. Neurology
|October 10, 2023
概括
神经认知障碍 (NCI) 持续存在于艾滋病毒感染者尽管治疗,由持续病毒和并发症驱动. 新的研究确定了与艾滋病毒相关的NCI的可用药物标和非药物干预措施,为人们提供了希望.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗逆转录病毒疗法抑制HIV复制,但不能消除病毒,留下神经退行的潜力.
- 糖尿病等并发症和抗逆转录病毒疗法的副作用有助于艾滋病毒感染者的中枢神经系统 (CNS) 损伤.
- 由于复杂的病理生理学和多样化的临床表现,艾滋病毒相关的神经认知障碍 (NCI) 缺乏经批准的治疗方法.
研究的目的:
- 审查HIV相关的NCI背后的机制.
- 确定潜在的治疗目标和干预措施,以管理艾滋病毒感染者的NCI.
- 通过突出最近的进展,为患者和护理人员提供乐观感.
主要方法:
- 关于艾滋病毒神经病变发生的文献综述.
- 对潜在的可用药物目标进行分析.
- 讨论药理和非药理干预措施.
主要成果:
- 与艾滋病毒相关的NCI是复杂的,可能是由多个因素而不是单一机制引起的.
- 新兴的目标包括免疫激活,线粒体功能障碍,金属离子和溶酶体失调以及微生物组变化.
- 除了药物治疗,非药物干预也很重要.
结论:
- 尽管面临挑战,但最近的发现为治疗艾滋病毒相关的NCI提供了有希望的途径.
- 针对各种机制的多方面的方法对于有效的干预至关重要.
- 对这些目标和干预措施的进一步研究可以改善艾滋病毒和NCI患者的治疗结果.
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