14-3-3蛋白抑制CaMKK1通过阻断其最后两个C终端螺旋体的激酶活性部位来抑制CaMKK1

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Updated: Jul 14, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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Olivia Petrvalska1,2, Karolina Honzejkova1, Nicola Koupilova1

  • 1Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic.

Protein science : a publication of the Protein Society
|October 10, 2023
PubMed
概括

这项研究揭示了14-3-3蛋白与CaMKK1和CaMKK2.2的结合方式的结构差异. 这就解释了为什么14-3-3结合会抑制CaMKK1而不是CaMKK2,影响细胞过程.

关键词:
14-3-3 蛋白质的使用情况这就是CaMKKKK.萨克斯 (SAXS) 的时间/ 卡尔莫杜林依赖的蛋白质激酶.光光谱学 光光谱学/交换与MS相结合,与MS相结合蛋白质与蛋白质的相互作用

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