专业头痛护理中的三非响应:来自DMKG头痛登记处的截面数据
Ruth Ruscheweyh1,2,3, Gudrun Gossrau4, Thomas Dresler5,6,7
1Department of Neurology, LMU University Hospital, LMU Munich, Marchioninistr. 15, Munich, 81377, Germany. ruth.ruscheweyh@med.uni-muenchen.de.
The journal of headache and pain
|October 10, 2023
概括
大约13.1%的偏头痛患者经历了三抗药性,失败了两个或两个以上的三. 特里普坦失败与偏头痛严重程度的增加相关,突出了需要有效的急性治疗选择.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 头痛 医学 医学 医学
背景情况:
- 三药是一种常见的偏头痛治疗方法,但疗效和耐受性各不相同.
- 欧洲头痛联合会 (EHF) 将"三抗药"定义为两种或更多种三药的失效.
- 关于三抗药的频率的数据是有限的.
研究的目的:
- 为了确定在德国偏头痛患者队列中抗坦耐药性的频率.
- 为了调查抗坦和偏头痛严重程度之间的关联.
- 为了告知偏头痛的急性治疗策略.
主要方法:
- 利用了来自德国偏头痛和头痛协会 (DMKG) 头痛登记处的患者自我报告数据.
- 在2284名成年偏头痛患者中评估了三的反应,疗效和耐受性失败.
- 分析数据基于失败的三治疗的数量.
主要成果:
- 13.1%的患者符合EHF对三抗药的定义 (失败≥2个三).
- 与响应者相比,没有响应普坦的人表现出明显更高的偏头痛频率,强度和残疾.
- 鼻腔佐尔米特里普坦,口腔埃莱特里普坦和皮下苏马特里普坦显示了最高的响应率.
结论:
- 在德国专门的头痛护理中,13.1%的患者表现出抗抗药性.
- 特里普坦失败与偏头痛严重程度和残疾增加有关.
- 优化急性偏头痛治疗可能涉及切换三药或药物类别.
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