用于预测乳腺粘膜癌患者接受化疗和手术的存活率的诺莫图:基于人口的研究
Ting Gao1,2, Yuyuan Chen1,3, Ming Li1
1The 2Nd Department of Breast Surgery, Breast Cancer Center of the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Building 3, No. 519 Kunzhou Road, Kunming, 650118, China.
European journal of medical research
|October 10, 2023
概括
一种新的诺米图准确地预测了乳腺粘膜癌 (MuBC) 患者在化疗和手术后的生存率. 该工具有助于制定针对MuBC的个性化治疗策略.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
- 癌症研究 癌症研究
背景情况:
- 粘性乳腺癌 (MuBC) 是罕见的,阻碍了广泛的预后研究.
- 准确的预后对于 MuBC 患者个性化治疗策略至关重要.
研究的目的:
- 开发和验证乳腺粘膜癌患者的预后模型.
- 改进个人化治疗规划,为MuBC幸存者.
主要方法:
- 利用了SEER数据库 (2004-2015) 对1668名MuBC患者的数据.
- 采用考克斯回归分析来确定预后因素.
- 使用内部 (SEER) 和外部 (YNCC) 数据集构建和验证了一个名录.
主要成果:
- 确定年龄,解剖阶段,手术方法和放射治疗作为关键的预后因素.
- 诺米图表显示出强大的预测准确度,一致性指数为0.680 (训练),0.768 (内部) 和0.864 (外部).
- 校准曲线和决策曲线分析证实了名图的临床实用性和预测能力.
结论:
- 开发的诺米图可靠地预测化学疗法和手术后的MuBC患者的整体存活率.
- 这种预后工具可以指导为MuBC患者创建个性化治疗计划.
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