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在儿童中,FTO变异和前前大脑早期发育

Gita Thapaliya¹, Poorbita Kundu², Elena Jansen¹

¹Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Obesity (Silver Spring, Md.)

|October 11, 2023

概括

与FTO基因变异相关的肥胖遗传风险影响早期大脑发育. 患有肥胖风险等位基因的儿童在关键的发育年份表现出改变的核积体体积.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
发展心理学发展心理学

背景情况:

与肥胖相关的遗传变异,特别是在脂肪质量和肥胖相关 (FTO) 位点,与饮食行为有关.
这些FTO变体与参与奖励处理的前前大脑区域的结构和功能的变化有关.

研究的目的:

调查FTO基因的变异如何影响幼儿时期前腹胃口回路的发展.
在发育过程中检查FTO基因型和大脑体积轨迹之间的关系.

主要方法:

利用了关于早期大脑发育的RESONANCE纵向研究的数据.
在228名使用MRI的儿童中检查了大脑体积增长轨迹 (核,额叶,总灰白质).
分析的数据基于FTO单核酸多态 rs9939609风险等位基因 (AA) 载体状态,性别控制,BMI z-score和母亲教育.

主要成果:

携带FTO风险等位基因 (AA) 的儿童与没有风险等位基因 (TT) 的儿童相比,表现出更大的核体积.
核体积 (调整为大脑总体积) 的这种差异在大约2至6岁 (750至2250天) 之间观察到.

结论:

肥胖的共同遗传风险与大脑的奖励回路中明显的早期发育模式有关.
强调研究基因型,大脑发育,行为和体重之间的动态相互作用在整个生命周期中的重要性.

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