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调节碳点支持的Fe单原子纳米酶的协调环境,用于增强瘤治疗

Yu Han¹, Kun Ge¹, Ying Zhao²

¹Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, State Key Laboratory of New Pharmaceutical Preparations and Excipients, College of Chemistry and Materials Science, Hebei University, Baoding, 071002, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|October 11, 2023

概括

新的碳点支持的铁单原子纳米酶显示了癌症治疗中增强的过氧化酶类活性. 这些纳米酶通过结合化学动力学和光热效应有效地抑制瘤生长.

科学领域:

纳米技术纳米技术
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

开发有效的纳米酶用于生物医学应用.
现有纳米酶在活性和特异性方面的局限性.
单原子纳米酶 (SAzymes) 对增强催化性能的潜力.

研究的目的:

制造新的碳点 (CD) 支持的Fe单原子纳米酶 (ph-CDs-Fe SAzyme),使用一种由类素介导的联体辅助策略.
为了研究ph-CDs-Fe SAzyme的增强型过氧化酶 (POD) 类活性,与没有类素的对应物相比.
通过协同化学动力学和光热效应来评估ph-CDs-Fe SAzyme的抗瘤疗效.

主要方法:

通过联体辅助策略制造ph-CDs-FeSAzyme.
使用偏差校正的高角度环状暗场扫描传输电子显微镜 (HAADF-STEM) 和X射线吸收细结构光谱 (XAFS) 进行了表征.
稳态动力学研究和密度函数理论 (DFT) 计算,以评估催化活性和反应机制.
在体外和体外的抗瘤疗效实验.

主要成果:

Ph-CDs-Fe SAzyme的POD类活性明显高于CDs-Fe SAzyme的POD类活性,这归因于类似于费里波的结构.
HAADF-STEM和XAFS证实Fe分散在碳点中的单个原子中.
动力学研究显示,ph-CDs-FeSAzyme的H2O2裂变的Vmax和kcat是3.0倍和6.2倍的.
DFT的计算显示,ph-CDs-FeSAzyme催化反应的能量屏障较低.
Ph-CDs-Fe SAzyme在体外和体内都证明有效抑制瘤细胞生长.

结论:

开发了一种新的策略,用于制造高度活跃的Fe单原子纳米酶,支持碳点.
ph-CDs-Fe SAzyme的独特结构导致了优异的过氧化酶类活性.
这些SA酶为开发有效的抗瘤治疗方法提供了一个有希望的新范式,利用协同化学动力学和光热效应来开发有效的抗瘤治疗方法.

关键词:

碳点是指碳点的部分.化学动力学疗法是一种化学动力学疗法.环境协调环境协调光热疗法是一种光热疗法.一个原子的纳米酶.

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