来自癌症的非编码RNA赋予瘤微环境免疫抑制性质
1Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wiley interdisciplinary reviews. RNA
|October 11, 2023
概括
癌症衍生的非编码RNAs (ncRNAs) 促进瘤免疫抑制微环境 (TIME) 的形成,有助于免疫疗法耐药性. 针对这些ncRNAs提供了改善癌症治疗的潜力.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 免疫学 免疫学 免疫学
背景情况:
- 非编码RNAs (ncRNAs) 在癌症的发展和进展中发挥着关键作用.
- 瘤免疫疗法耐药性是癌症治疗的一个主要挑战,通常与瘤微环境有关.
- 来自癌症的ncRNAs有助于免疫抑制瘤微环境 (TIME).
研究的目的:
- 总结癌症衍生的ncRNAs在调节TIME形成中的作用.
- 探索ncRNAs作为预后生物标志物和免疫治疗点的潜力.
- 为了解决TIME介导的免疫疗法耐药性.
主要方法:
- 文献综述和关于ncRNAs和TIME的当前研究的综合.
- 分析ncRNAs影响免疫细胞和信号通路的机制.
- 探索ncRNA在促进免疫逃避和免疫抑制方面的功能.
主要成果:
- 来自癌症的ncRNAs促进免疫检查点连接体表达 (例如PD-L1) 和免疫抑制性细胞因子分泌 (例如TGF-β).
- 通过细胞外囊泡转移的ncRNA抑制了细胞毒性T细胞和NK细胞.
- ncRNAs诱导髓质衍生抑制细胞 (MDSCs) 和瘤相关巨细胞 (TAMs) 中的免疫抑制表型.
结论:
- 来自癌症的ncRNAs是免疫抑制瘤微环境的关键调节者.
- ncRNAs代表了对预后和癌症免疫治疗的潜在目标有前途的生物标志物.
- 向ncRNAs可能会克服由 TIME 驱动的免疫疗法抵抗.
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