和多基基物质和心脏代谢性疾病:一篇综述
Tessa Schillemans1, Carolina Donat-Vargas1,2,3, Agneta Åkesson1
1Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Basic & clinical pharmacology & toxicology
|October 11, 2023
概括
和多基基物质 (PFAS) 是广泛存在的污染物,与健康问题有关. 研究表明,PFAS可能会影响心脏代谢疾病,但证据不一致,需要进一步的机制研究.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 和多基基物质 (PFAS) 是对人类健康造成重大关注的持续性环境污染物.
- 暴露于PFAS与脂质代谢和免疫功能中断有关,这表明它在心脏代谢疾病中起作用.
- 目前关于PFAS和心血管疾病或2型糖尿病的流行病学证据有限且不一致.
研究的目的:
- 审查关于PFAS和心脏代谢疾病的流行病学证据.
- 探索潜在的分子机制,利用欧米克和实验室数据来研究观察到的关联.
- 整合多样化的研究类型,以增强机械学理解和因果推理.
主要方法:
- 对PFAS和心血管疾病/2型糖尿病的流行病学研究进行系统审查.
- 综合来自OMICS和实验室研究的证据.
- 开发一个不良结果路径 (AOP) 框架,将分子事件与健康结果联系起来.
主要成果:
- PFAS可能与多个分子通路有关,其中一些可能对疾病风险产生相反的影响.
- 观察到的关联可以通过化学混合物组成,生活方式和遗传变异等因素来修改.
- 该审查强调了影响PFAS相关健康风险的复杂相互作用.
结论:
- 流行病学发现的不一致性可能源于复杂的分子机制和修饰因素.
- 极需进行暴露组研究,以考虑化学混合物和多组组数据.
- 综合流行病学和实验室研究对于强有力的环境健康风险评估和了解PFAS影响至关重要.
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