身体活动和膀癌风险:日本协作队列研究的发现
Hang An1,2,3, Keyang Liu1, Kokoro Shirai1
1Division of Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Cancer research and treatment
|October 11, 2023
概括
定期体育活动,包括娱乐运动和职业站立/行走,显著降低了日本成年人,特别是男性的膀癌风险. 这一发现解决了先前对亚洲人口的研究中的不一致性.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 身体活动与膀癌风险之间的联系受到争论,特别是在亚洲人群中.
- 现有的研究对这种关联提出了不一致的发现.
研究的目的:
- 研究身体活动水平与膀癌发病率之间的关系.
- 在一个大规模的日本队列中分析这种关联.
主要方法:
- 一项基于人口的前性队列研究,涉及50374名日本成年人 (40-79岁).
- 参与者填写了关于身体活动的自我管理问卷.
- 考克斯比例危险模型用于估计危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在平均17.5年的时间里,发现了153例膀癌.
- 较高水平的休运动参与 (≥5小时/周) 显示出与膀癌风险有显著的反向关联 (HR,0.28).
- 职业体力活动 (站立/走路) 也与降低风险有关 (HR,0.53).
结论:
- 娱乐运动和职业体育活动都与日本人口的膀癌风险相反相关.
- 这种保护作用在男性中显得更加明显.
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