类固醇剂摄入量与中风后肺炎风险之间的关联:系统性审查和元分析
Mohammad Darvishi1, Mehdi Mohammadian Amiri2, Saeid Heidari-Soureshjani3
1Infectious Diseases and Tropical Medicine Research Centre (IDTMRC), Department of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran.
Current reviews in clinical and experimental pharmacology
|October 11, 2023
概括
这次系统性审查没有发现他类药物使用与中风后肺炎风险之间的联系. 对68,966名参与者的元分析显示没有显著的关联,表明他类药物不会增加中风后肺炎的风险.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 脑卒中后肺炎是一种影响患者结果的严重并发症.
- 类药物通常用于心血管健康,但它们对中风后并发症的影响需要澄清.
研究的目的:
- 系统地审查和对有关他类药物摄入量和中风后肺炎风险的现有研究进行元分析.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2023年3月21日.
- 包括7项观察性研究 (5个队列,2个病例控制) 涉及68,966名参与者.
- 纽卡斯尔太华尺度评估了研究质量;使用统计测试和漏斗图表评估了异质性和出版偏差.
主要成果:
- 七项研究的元分析发现,他类药物使用与中风后肺炎之间没有统计学上显著的关联 (几率比=0.87,95% CI:0.67-1.13,p=0.458).
- 对队列和病例控制研究的子组分析也没有显示出任何显著联系.
- 没有发现出版偏差的证据.
结论:
- 这一元分析表明,他类药物治疗与中风后肺炎风险增加无关.
- 可能需要进一步的研究,但目前的证据表明,他类药物不会增加这种特定的并发症风险.
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