脊髓保护用于胸腔腹腔大动脉动脉瘤修复:从长椅到床边
Adam M Carroll1, R Wilson King1, Christian V Ghincea1
1Division of Cardiothoracic Surgery, Department of Surgery, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, USA.
Annals of cardiothoracic surgery
|October 11, 2023
概括
大动脉手术期间的脊髓损伤通常是由血流不良和缺血-再输血引起的. 优化脊髓输液和耐受性对于防止毁灭性的患者结果至关重要.
科学领域:
- 心血管外科心血管外科
- 神经学 神经学
- 血管生物学 血管生物学
背景情况:
- 脊髓损伤 (SCI) 是大动脉手术后的一种严重并发症.
- 了解SCI的机制对于改善患者的结果至关重要.
研究的目的:
- 在大动脉手术的背景下,审查SCI的解剖学和病理生理学.
- 讨论SCI的风险因素,机制和神经保护策略.
主要方法:
- 在大动脉外科手术中对SCI进行实验室和临床研究的审查.
- 检查影响脊髓输液和缺血性耐受性的因素.
主要成果:
- 关键机制包括直接/附带脊髓输液损失和缺血-再输液损伤.
- 目前的神经保护策略正在临床实践中进行评估.
结论:
- 需要采用综合方法来优化脊髓血液流动,担保和缺血耐受性.
- 由于其灾难性后果,对SCI的持续研究至关重要.
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