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高血清瘦素水平与乳腺甲状腺癌的关联:一个病例对照研究
Roya Refahi1, Zahra Heidari1, Mohammadali Mashhadi1
1Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.
International journal of hematology-oncology and stem cell research
|October 11, 2023
概括
与良性甲状腺结节 (BTN) 和健康对照组相比,乳腺甲状腺癌 (PTC) 患者的血清瘦素水平显著更高. 这表明丁可以作为PTC的潜在瘤标志物.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 代谢研究研究 代谢研究
背景情况:
- 甲状腺癌的发病率正在上升,目前的风险因素不足以解释这种增加.
- 肥胖的患病率也在增加,涉及诸如勒素等因素.
- 莱普在促进细胞存活,增殖和血管生成方面的已知作用表明它与癌症发展有关.
研究的目的:
- 在患有乳头甲状腺癌 (PTC) 的患者中检查血清勒丁水平.
- 为了比较PTC患者,良性甲状腺结节 (BTN) 患者和健康对照者之间的瘦素水平.
- 探索丁和PTC和BTN中的临床参数之间的相关性.
主要方法:
- 横截面研究包括新诊断的PTC患者,BTN病例和健康对照.
- 在所有参与者中测量血清瘦素水平和甲状腺功能测试.
- 在甲状腺切除术后的PTC患者中评估勒丁.
主要成果:
- 与BTN (17.60 ng/ml) 和对照组 (13.83 ng/ml) 相比,PTC患者 (22.34 ng/ml) 的血清瘦素水平显著升高 (P<0.001).
- 在PTC患者中,瘦素与BMI,瘤大小和瘤阶段有显著的关联.
- 在患有良性甲状腺结核的患者中,丁与BMI和瘤大小相关.
结论:
- 血清勒丁水平升高与乳头甲状腺癌有关.
- 丁可以作为PTC的潜在诊断或预后生物标志物.
- 需要进一步的研究来阐明丁在甲状腺癌发病过程中的作用.
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