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在乳头甲状腺癌中循环RNA调节网络的综合分析

Ji Young Kim¹, Yeongun Lee¹, So Hee Dho¹

¹Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine Seoul, Republic of Korea.

American journal of cancer research

|October 11, 2023

概括

这项研究确定了两种循环RNA (circRNA) 和四种微RNA (miRNA) 作为乳头甲状腺癌 (PTC) 进展的关键调节剂. 这些发现突出了改善PTC诊断和向治疗的潜在生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳头甲状腺癌 (PTC) 是最常见的内分泌癌症,经常与淋巴结转移和复发有关.
循环RNAs (circRNAs) 正在成为瘤进展途径的关键调节者.

研究的目的:

为了确定新型circRNAs作为皮肤状甲状腺癌 (PTC) 的潜在生物标志物.
阐明PTC进展中的circRNA-miRNA-mRNA的调节网络.

主要方法:

从公共数据集 (GEO,TCGA) 中分析差异表达的circRNA和mRNA.
使用在线预测数据库对目标miRNA进行查.
通过蛋白质-蛋白质相互作用分析构建一个circRNA-miRNA-mRNA调节网络并识别枢纽基因.
功能丰富和生存分析,以了解 circRNA 的作用.

主要成果:

确定了两个关键的circRNAs (hsa_circ_0041829,hsa_circ_0092299) 和四个miRNAs (miR-369,miR-486,miR-574,miR-665),它们都与PTC有显著的关系.
建立了一个监管网络,涉及9个枢纽基因 (例如,BBC3,E2F1,TYMS) 在PTC进展中.
证明了这些分子在PTC发展和患者存活中的重要作用.

结论:

这项研究为了解PTC中circRNA-miRNA介导的基因调节提供了一个新的框架.
确定了PTC的潜在治疗目标和预后生物标志物.
这些发现可能构成开发针对PTC的有针对性的治疗干预措施的基础.

关键词:

乳头甲状腺癌是一种乳头甲状腺癌.生物标志物生物标志物圆形的RNARNA是一个圆形的RNA.监管网络监管网络监管网络监管网络监管

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