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生物信息学分析和实验验证确定了HMGA2/microRNA-200c-3p/LSAMP/Wnt轴作为结直肠癌患者的免疫因素

Xi Xu¹, Chaoju Gong², Yunfeng Wang³

¹Department of Pathology, Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310009, Zhejiang, China.

American journal of cancer research

|October 11, 2023

概括

这项研究开发了瘤微环境 (TME) 相关的结直肠癌 (CRC) 患者的风险评分. 较低的得分预测更好的生存率和免疫治疗反应,突出显示CRC瘤免疫学中的HMGA2/microRNA-200c-3p/LSAMP/Wnt轴.

科学领域:

在瘤免疫学上.
癌症基因组学癌症基因组学
分子瘤学分子瘤学

背景情况:

大肠直肠癌 (CRC) 是一种普遍存在的恶性瘤,瘤微环境 (TME) 显著影响患者的预后.
描述TME和确定CRC的预后生物标志物仍然是关键的挑战.

研究的目的:

在CRC中识别免疫和 stromal 相关基因.
开发和验证TME相关风险评分模型,用于预测CRC患者的预后和免疫治疗反应.

主要方法:

对差异表达基因和TME相关模块的综合分析.
风险模型构建的Lasso-Cox回归.
在癌症基因组图谱 (TCGA) 和基因表达综合 (GEO) 数据集中的验证.
对LSAMP的实验验证和对HMGA2/microRNA-200c-3p/LSAMP/Wnt轴的机械研究.

主要成果:

建立了一个TME相关风险得分,高得分表明不同患者亚组的预后不利.
在高风险组中经常发生突变的10个基因可能会影响TME和免疫治疗反应.
较低的风险得分与更好的免疫疗法反应和整体存活率相关.
鉴定出LSAMP是一种增强CRC对CD8+T细胞细胞毒性敏感性的基因.

结论:

与TME相关的风险评分作为CRC可靠的预后生物标志物.
在CRC的免疫学中,HMGA2/microRNA-200c-3p/LSAMP/Wnt轴起着重要的作用.
针对这一轴可能为CRC患者提供治疗潜力.

关键词:

这就是HMGA2的原因.对于LSAMP来说,这是一个很大的问题.没有信号发送.结肠直肠癌是什么意思微型RNA-200c-3pp是什么意思在对抗免疫学上.

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