病例报告:在小型小牛犬中,同时存在中枢垂体低甲状腺症和没有垂体腺瘤的高 adrenocorticism
Yeon Chae1, Taesik Yun1, Yoonhoi Koo1
1Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Frontiers in veterinary science
|October 11, 2023
概括
这项研究详细介绍了一种罕见的犬类病例,该病例在迷你小牛犬中同时出现中枢垂体甲状腺功能低下症和非上腺皮质过高症. 两种内分泌疾病的有效管理得到了实现,改善了临床症状.
科学领域:
- 兽医内分泌学 兽医内分泌学
- 狗内科 狗内科 狗内科
- 进行比较内分泌学.
背景情况:
- 多重内分泌疾病在兽医中很少见,通常与高皮质醇或自身免疫有关.
- 中部下垂体甲状腺功能低下症是高皮质醇症的次要症状,在人类中已知,但在狗中很少报告.
- 同时出现的高 adrenocorticism 和中央甲状腺功能低下症在兽医实践中是一个诊断和治疗的挑战.
研究的目的:
- 描述了一种罕见的狗狗中存在的中部-垂体甲状腺功能低下症和非上腺依赖性高 adrenocorticism 的罕见病例.
- 记录多种内分泌病的诊断方法和成功的管理策略.
- 为了有助于理解复杂的内分泌疾病组合在犬医学.
主要方法:
- 激素检测以诊断高 adrenocorticism 和中央甲状腺功能低下症.
- 先进的成像 (MRI,PET) 排除垂体病变.
- 顺序管理,优先控制过上腺皮质,然后进行甲状腺功能低下症治疗.
- 长期监测临床症状和激素水平.
主要成果:
- 一只迷你犬被诊断出同时患有非上腺依赖的高 adrenocorticism 和中央垂体甲状腺功能低下症.
- 尽管进行了先进的成像,但没有发现下垂体宏腺瘤.
- 联合治疗导致9个月内临床改善和控制两个内分泌条件.
- 甲状腺刺激激素水平始终无法测量.
结论:
- 这一案例突出显示,即使没有垂体病变,狗身上也可能同时出现中枢垂体低甲状腺症和非上腺皮质过高症.
- 一个分阶段的治疗方法可以有效地管理这些复杂的多重内分泌病变.
- 需要进一步的研究,以了解这种结合性内分泌疾病的潜在机制和长期影响.
相关概念视频
Adrenal Gland Disorders
1.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
Major Hormones and Their Functions
457
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
457
Hypothalamic-Pituitary Axis
60.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.3K
The Thyroid Gland
4.0K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.0K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
1.3K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.3K
Hormones of the Adrenal Glands
2.5K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.5K


