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探索甲状腺功能与口腔微生物群多样性之间的关联:一个NHANES分析
Liang Zheng1, Rui Yang2, Ruixia Li1
1Department of Thyroid Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Journal of the Endocrine Society
|October 11, 2023
概括
甲状腺功能会影响口腔健康. 甲状腺功能障碍与口腔微生物群多样性较低有关,而甲状腺激素水平可能会改变口腔微生物组成.
科学领域:
- 口腔微生物组研究
- 内分泌学 在内分泌学.
- 微生物组和宿主相互作用
背景情况:
- 口腔微生物组在保持口腔健康方面发挥着至关重要的作用.
- 甲状腺功能障碍,包括甲状腺功能障碍,可以影响各种身体系统.
- 了解甲状腺功能和口腔微生物群落之间的相互作用对于全面的健康评估至关重要.
研究的目的:
- 调查甲状腺功能与口腔微生物群多样性之间的关联.
- 探索甲状腺激素和相关生物标志物与口腔微生物组成的相关性.
主要方法:
- 来自美国国家健康和营养检查调查 (NHANES; 2009-2012) 的数据分析.
- 使用甲状腺激素和生物标志物的甲状腺功能评估.
- 使用安普利康序列变异 (ASV) 和布雷-库蒂斯不相似度测量口腔微生物群多样性.
- 统计分析包括线性回归和非度量多维缩放 (NMDS).
主要成果:
- 总共分析了2943名参与者.
- 自我报告的甲状腺疾病与减少的口腔微生物群多样性 (减少的ASVs) 有关.
- 亚临床和临床甲状腺功能障碍与口腔微生物群多样性减少显著相关.
- 增加的甲状腺过氧化酶抗体水平与增加的口腔微生物群多样性 (更高的ASVs) 相相关.
- 甲状腺激素水平 (自由三甲状腺素,自由甲状腺素) 和甲状腺蛋白水平在口腔微生物组合中显示出显著的差异.
结论:
- 甲状腺功能障碍与口腔微生物群多样性的减少有关.
- 特定的甲状腺功能标记物,包括自由三甲状腺素,自由甲状腺素和甲状腺蛋白,可能会影响口腔微生物组的组成.
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