弗拉克塔尔金类型的年龄相关变化及其对神经退行性疾病的贡献
Jaime Eugenín1, Laura Eugenín-von Bernhardi2, Rommy von Bernhardi3
1Facultad de Química y Biología, Departamento de Biología, Universidad de Santiago de Chile, USACH, Santiago, Chile.
Frontiers in molecular neuroscience
|October 11, 2023
概括
弗拉克塔尔金 (CX3CL1) 存在于膜结合和可溶性形式,可以差异调节微质,影响神经元-质相互作用. 这些形式的不平衡与神经炎症和神经退行性疾病有关.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 弗拉克塔尔金 (CX3CL1) 是一种CX3C化学基因,对神经元-质沟通和微质调节至关重要.
- 它存在于膜结合 (mCX3CL1) 和溶解 (sCX3CL1) 形式,主要与微质上CX3CR1受体相互作用.
研究的目的:
- 审查影响弗拉克塔尔金形式生成和年龄相关变化的因素.
- 探索弗拉克塔尔金类型在神经炎症和神经退行症中的不同作用.
- 为了突出fractalkine平衡对神经元-微质相互作用的影响.
主要方法:
- 文献综述,重点关注碎蛋白生物及其在神经疾病中的作用.
- 对研究mCX3CL1和sCX3CL1.1的不同功能进行分析.
- 综合证据表明,与老龄化,神经炎症和神经退行相关联的法克塔尔基因失调.
主要成果:
- 碎类型 (mCX3CL1,sCX3CL1) 对微质细胞具有选择性和差异性影响.
- 激活CX3CR1会影响神经发育,突触功能,认知和炎症.
- 已经观察到分素形式的促炎和抗炎作用.
结论:
- 不同类型的fractalkine之间的平衡对于保持健康的神经元-微质相互作用至关重要.
- 弗拉克塔尔金类型的年龄相关变化可能会导致慢性中枢神经系统炎症和神经退行.
- 弗拉克塔尔金信号的失调代表了衰老,神经炎症和神经退行过程的融合点.
相关概念视频
Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K
Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
Enzyme-linked Receptors
78.6K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
78.6K
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K


