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Updated: Jul 13, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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胡素类化合物:四十年的总合成

Bichu Cheng1,2, Lili Song1, Fener Chen1,3,2

  • 1Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China. rfchen@fudan.edu.cn.

Natural product reports
|October 11, 2023
PubMed
概括

包括huperzine A在内的huperzine类化合物是具有独特结构和强大的乙胆酶 (AChE) 抑制活性的天然产品. 它们的合成推动了合成有机化学的重大进展.

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Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview01:07

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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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Introduction
Alkynes can be prepared by dehydrohalogenation of vicinal or geminal dihalides in the presence of a strong base like sodium amide in liquid ammonia. The reaction proceeds with the loss of two equivalents of hydrogen halide (HX) via two successive E2 elimination reactions.
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