在急性缺血性中风治疗中,Cerebrolysin
Liliya Eugenevna Ziganshina1,2,3, Tatyana Abakumova4, Dilyara Nurkhametova1
1Centre for Knowledge Translation, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education", The Ministry of Health of the Russian Federation (RMANPO), Moscow, Russian Federation.
The Cochrane database of systematic reviews
|October 11, 2023
概括
脑素是一种混合物,对于急性缺血性中风患者来说,它可能在死亡率或严重不良事件方面没有显著的益处. 然而,可能会增加非致命的严重不良事件,需要谨慎.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 来自猪大脑的和氨基酸混合物cerebrolysin用于神经保护.
- 在几个国家,它被广泛用于急性缺血性中风.
- 本次审查是对2010年和2020年之前分析的更新.
研究的目的:
- 评估Cerebrolysin和类似药物的有效性和安全性,用于治疗急性缺血性中风.
- 评估Cerebrolysin对急性缺血性中风患者的益处和危害.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了多个数据库,包括Cochrane中风试验注册,MEDLINE,Embase和俄罗斯数据库,直到2022年5月/6月.
- 包括RCT比较Cerebrolysin或类似药物与安慰剂/没有治疗在中风发作后48小时内.
主要成果:
- 包括7个RCT (1773名参与者);在此更新中增加了Cortexin的一个RCT.
- 在所有死因 (中度确定性证据) 中,cerebrolysin 几乎没有差异.
- 观察到非致命的严重不良事件的潜在增加 (中等确定性证据).
结论:
- 脑素和类似的混合物可能对预防急性缺血性中风的全因死亡没有显著的益处.
- 赛博洛林似乎对严重不良事件的总数没有有益影响.
- 有证据表明,与Cerebrolysin使用相关的非致命严重不良事件的潜在增加.
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