由于中毒造成的临时甲状腺功能障碍和甲基荷胺过量在6例病例中
Yavuz Özer1, Mehmet Yıldız2, Hande Turan1
1Department of Pediatric Endocrinology, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Turkey.
Turkish archives of pediatrics
|October 11, 2023
概括
中毒可能会导致甲状腺功能障碍和染细胞瘤样综合征,导致高血压和低心率. 早期诊断和治疗对于预防严重的健康后果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
- 内部医学 内部医学
背景情况:
- 中毒是一种严重的疾病,影响多个器官系统,包括中枢神经系统,心血管系统和脏.
- 虽然已知其系统性影响,但暴露于的内分泌后果并没有得到很好的描述.
- 及时诊断和治疗至关重要,以防止可能致命的结果和长期的后果,如神经障碍.
研究的目的:
- 研究和评估被诊断患有中毒的患者的内分泌学影响.
- 为了确定与毒性相关的特定内分泌异常.
- 提高人们对中毒的认识,作为无法解释的内分泌和心血管症状的差异诊断.
主要方法:
- 一个案例系列研究,涉及3个家庭的6名患者,有确定的中毒.
- 详细记录所有参与者的临床表现,实验室发现和随访数据.
- 对内分泌和心血管参数的分析,以确定功能障碍的模式.
主要成果:
- 甲状腺功能障碍,以高甲状腺激素和正常的甲状腺激素水平为特征,在83.3%的病例中观察到.
- 在83.3%的患者中,存在具有高血压的染细胞瘤样综合征.
- 在50%的病例中发现了低血症,4名患者需要甲基马来控制对其他治疗无反应的高心率和高血压.
结论:
- 中毒呈现出不特定的发现,使得早期诊断具有挑战性.
- 内分泌功能障碍,特别是甲状腺异常和类似染细胞瘤的综合征,是中毒的显著表现.
- 考虑到在患有不明原因高血压和心跳动的患者中中毒,对于及时干预和预防并发症至关重要.
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